Drugs and gingival bleeding

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Evaluation of the effect of enoxolone-containing toothpaste on dental plaque, gingival inflammation and bleeding indices

Background and Aims: Enoxolon is a natural licorice and its formula is similar to cortisone. The aim of this double blind randomized match control clinical trial, was to analyze the effect of Arthrodont toothpaste containing 1% Enoxolone on dental plaque, gingival inflammation, and bleeding indices. Materials and Methods: 40 patients who had gingivitis were selected. They were instructed to br...

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Excessive gingival bleeding in two patients with Glanzmann thrombasthenia.

BACKGROUND Glanzmann thrombasthenia (GT) is an exceedingly rare but well-defined inherited disorder of platelet function caused by a defect in the glycoprotein IIb/IIIa complex. The association of GT with consanguinity has been noted, especially in geographic regions in which intermarriage is common. In most patients, GT is diagnosed during early infancy or before the age of 5 years. Common man...

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Aminaphtone in the control of gingival bleeding in children

AIM The objective of the current study was to evaluate the efficacy of aminaphtone to control gum bleeding. PATIENTS AND METHODS Fifteen male and 15 female children, aged between 10 and 18 years with a mean age of 13.4 years and with gingival bleeding, were enrolled in this randomized, double-blind, placebo-controlled, Phase IV clinical trial. The inclusion criterion was gingivitis with gingi...

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Cytokine secretion in cultured human gingival fibroblasts in response to LPS or gingival overgrowth-inducing drugs

Human normal, periodontitis and overgrown gingival fibroblasts were assayed concerning proinflammatory cytokines secreting ability. Stimulating effect of gingival overgrowth-inducing drugs such as phenytoin, nifedipine or cyclosporine A and LPS on the secretion ability of each fibroblast specimen was also estimated. The supernatant of cultured medium was assayed cytokines by ELISA techniques. I...

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Accumulation of non-steroidal anti-inflammatory drugs by gingival fibroblasts.

Non-steroidal anti-inflammatory drugs (NSAIDs) are used to manage pain and inflammatory disorders. We hypothesized that gingival fibroblasts actively accumulate NSAIDs and enhance their levels in gingival connective tissue. Using fluorescence to monitor NSAID transport, we demonstrated that cultured gingival fibroblasts transport naproxen in a saturable, temperature-dependent manner with a K(m)...

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ژورنال

عنوان ژورنال: Australian Prescriber

سال: 2006

ISSN: 0312-8008,1839-3942

DOI: 10.18773/austprescr.2006.094